Lichenoid drug eruption
Overview
- Differentiation from classic LP:
- Predilection sites: Different from classic LP (e.g., trunk, extensor surfaces)
- Wickham's striae: Absent (no mucous membrane involvement)
- Temporal correlation: Medication intake weeks to months before onset
- Common Triggers: NSAIDs, antimalarials, beta-blockers.
Note: A current AWMF guideline specifically for lichenoid LDE does not exist at present (as of 2024). Medications: Gelbe Liste:
Overview
- Latency: 2–4 weeks, also months later with checkpoint inhibitors.
- Trigger 1: checkpoint inhibitors or beta-blockers.
- Trigger 2: antimalarials or ACE inhibitors.
- Clinical presentation: Trunk-predominant lichenoid, itchy papules.
- Histology: band-like lymphocytic infiltrate at the dermo-epidermal junction, Civatte bodies.
Differential diagnoses
- Lichen planus
- Pityriasis rosea
- PLEVA (Pityriasis lichenoides et varioliformis acuta)
- Pityriasis lichenoides chronica (PLC)
- Mycosis fungoides
- Graft-versus-host disease (GvHD)
- Secondary syphilis (lues II)
- Lichen nitidus
Practise Lichenoid drug eruption in the app
Flashcards with spaced repetition, exam questions and spot-the-diagnosis on this topic – in DermaFuchs, free of charge.
In the DermaFuchs app: 4 flashcards · 1 clinical images
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More inflammatory skin diseases
- Cheilitis granulomatosa (Miescher)
- Erythema annulare centrifugum (EAC)
- Erythema nodosum
- Graft-versus-host disease (GvHD)
- Granuloma annulare
- Cutaneous sarcoidosis
- Lichen planus
- Lichen sclerosus
Note: This page is intended for medical education and does not replace diagnosis or treatment decisions in individual cases. Treatment and follow-up content is available in the app.