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Epidermolysis bullosa simplex

By Dr. Pascal Bafteh · last updated 09/2026

Epidermolysis bullosa simplex: hemorrhagic blister on the foot after mechanical stress. — Khayman, „Pied épidermolyse bulleuse", CC BY-SA 3.0, via Wikimedia Commons · CC BY-SA 3.0 · Source

Overview

Reference: detailed in separate card "Hereditary Epidermolysis bullosa (EB)". Here are the key points.

EB Subtypes with Cleavage Planes

EB simplex: Keratin 5 / 14, Plectin — intraepidermal (basal keratinocyte)
EB junctionalis: Laminin 332, Collagen XVII (BP180) — lamina lucida
EB dystrophica: Collagen VII (COL7A1) — below lamina densa
Kindler syndrome: Kindlin-1 (FERMT1) — all layers + poikiloderma

Diagnostics: Immunofluorescence mapping of the cleavage plane + genetic analysis as gold standard.

Differential diagnoses

Epidermolysis bullosa acquisita
Porphyria cutanea tarda
Bullous pemphigoid
Linear IgA dermatosis
Impetigo
Pemphigus vulgaris

Practise Epidermolysis bullosa simplex in the app

Flashcards with spaced repetition, exam questions and spot-the-diagnosis on this topic – in DermaFuchs, free of charge.

In the DermaFuchs app: 7 flashcards · 3 clinical images

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Sources (selection)

Has 2020 EB Consensus

More hereditary skin diseases

Morbus Darier

Note: This page is intended for medical education and does not replace diagnosis or treatment decisions in individual cases. Treatment and follow-up content is available in the app.